In the core of the lens, mature fiber cells lack nuclei and organelles (1-3).
Mature lens fiber cells are characterized by slow protein turnover and increasing post-translational modifications such as proteolytic cleavage, glycation, and phosphorylation.
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In the presence of calmidazolium, a Ca M inhibitor, S235D showed high P regulation, suggesting that S235D still binds Ca M.
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